A movement of the magnitude required for Arizona to become truly competitive in science, engineering and medical research needs a compass. The vision statement presented in the 2002 Flinn-Battelle "Roadmap" report was just that. Given Arizona’s progress in bioscience and scientific research since then, the challenges for 2006 and beyond are to achieve that original vision and also to expand the state’s aspirations. The pathway provided in this document presents ten fundamental, collaborative steps for navigating toward this goal.