The Decision Center for a Desert City at Arizona State University—funded by the National Science Foundation since 2004—conducts research relevant to water resources and urban climate dynamics under multiple uncertainties. This report summarizes and synthesizes research findings and achievements of DCDC after almost a decade of research and science-policy interactions. Water resource decision-making is complicated by climate change and variability, population growth and economic development, diverse stakeholder interests and fragmented governance. While these factors generate various uncertainties and complexities for decision-makers, DCDC pursues research to create a more sustainable future. The DCDC contributes to water management and urban sustainability by conducting basic science and collaborating with policymakers and stakeholders to solve real-world problems. As detailed herein, DCDC research, education, and community outreach have made substantial contributions to improving water-resource governance and climate adaptation.