Tribes have a direct government-to-government relationship with the U.S. government wherein no decisions about their lands and people are made without their consent. In Arizona, for example, American Indian reservations occupy nearly 30 percent of the land. Native Americans have a legal and moral claim to significant quantities of water as well. Because of their special legal standing in the United States, tribes are not just another group of stakeholders to be considered in the research and policy process. The purpose of this paper is to provide a legal and political background for interactions between the United States and tribal governments and provide models for those interactions, with special attention to research and outreach.